Clinical Epidemiology: Evaluation of Medical Tests


Clinical Epidemiology: Evaluation of Medical Tests

By the end of this course, researchers are able to design studies to evaluate medical tests. These may be diagnostics, but also screening tests or predictive models. Participants will be able to choose the appropriate outcome measures, to design the appropriate study for these outcome measures and to indicate how to prevent biased results.


Four (online) sessions and an (optional) exam session

Scheduled dates

Edition 1: October 31 thru November 4, 2022

Edition 2: May 29 thru June 2, 2023

Target audience

PhD candidates who will be involved in a diagnostic study. Participants are assumed to be familiar with basic diagnostic accuracy and statistical concepts (sensitivity, specificity, predictive values).

Study Load

26 hours, which is comparable to 0.9 ECTS points.


Phases in test evaluation; inter- and intra-observer agreement; diagnostic accuracy studies; sensitivity and specificity, likelihood ratios, predictive values; ROC plots; patient selection; sources of bias for the different designs; designing a predictive modelling study; prospective versus retrospective designs; link between testing and patient outcome; power and sample size calculations; hypothesis testing.

Number of participants

Maximum 25 per course.

For PhD candidates who want to register as Epidemiologist B, a formal exam will be organized.

Course Coordinator

Dr. M.M.G. Leeflang

More information:

Geldige e-mail is verplicht Vraag is verplicht